Gap Junctions in Development and Disease: A Comprehensive Guide to Intercellular Communication

Gap junctions are remarkable structures that connect neighboring cells, forming a vital network for exchanging ions, molecules, and electrical signals. These channels play a pivotal role in various biological processes, including development, tissue homeostasis, and disease pathogenesis. "Gap Junctions in Development and Disease" is an authoritative guide that unravels the intricate world of intercellular communication, providing a comprehensive understanding of their functions, regulation, and therapeutic implications.

Gap Junctions in Development and Disease

by Doris Teichler Zallen

4.6 out of 5

Language	:	English
File size	:	4552 KB
Text-to-Speech	:	Enabled
Print length	:	296 pages

FREE

Unveiling the Roles of Gap Junctions in Development

During embryonic development, gap junctions orchestrate coordinated cell growth, differentiation, and tissue formation. They facilitate the sharing of nutrients, growth factors, and signaling molecules, enabling cells to communicate and respond to their surroundings. Disruption of gap junction function can lead to developmental abnormalities and birth defects, highlighting their critical role in shaping the body.

Gap Junctions in the Healthy and Diseased Heart

In the heart, gap junctions are essential for maintaining the rhythmic contractions that pump blood throughout the body. Their dysfunction can lead to cardiac arrhythmias, heart failure, and sudden cardiac death. Understanding the regulation of gap junctions in the heart is crucial for developing therapeutic strategies to prevent and treat heart disease.

The Impact of Gap Junctions on Nervous System Function

In the nervous system, gap junctions facilitate electrical signaling between neurons, enabling rapid and synchronized transmission of nerve impulses. Dysregulation of gap junctions can disrupt neural communication, leading to neurological disFree Downloads such as epilepsy, Parkinson's disease, and Alzheimer's disease.

Gap Junctions and Cancer

Gap junctions play a complex role in cancer progression. They can promote tumor growth by facilitating the spread of oncogenic signals and nutrients. Conversely, gap junction dysfunction can also suppress tumor growth by limiting cell proliferation and promoting cell death. Understanding the role of gap junctions in cancer can lead to novel therapeutic approaches.

Therapeutic Potential of Targeting Gap Junctions

Given their involvement in various diseases, gap junctions have emerged as potential therapeutic targets. Modulating their function using drugs or genetic interventions could provide new avenues for treating cardiac arrhythmias, neurological disFree Downloads, and cancer. The book explores the current state of gap junction research and discusses the challenges and opportunities in developing novel therapies.

"Gap Junctions in Development and Disease" is an invaluable resource for scientists, researchers, and students seeking to delve into the fascinating world of intercellular communication. Its comprehensive coverage, expert insights, and up-to-date research provide a solid foundation for understanding the roles of gap junctions in development, disease, and therapeutic interventions. This book is a must-read for anyone who wants to unravel the mysteries of cell-to-cell communication and unlock its potential for improving human health.

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Gap Junctions in Development and Disease

by Doris Teichler Zallen

4.6 out of 5

Language	:	English
File size	:	4552 KB
Text-to-Speech	:	Enabled
Print length	:	296 pages

FREE